| Name |
SIRT1 promoter
|
| Type |
promoter
|
| Species |
Homo sapiens
|
| Tissue |
lung fibroblast tissue
|
| Experiment Method |
Luciferase reporter assay,ChIP,qPCR,western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
SIRT1 (sirtuin 1) (Sir2 histone deacetylase) is an important determinant of longevity that plays a role in life-span regulation in diverse species .This study therefore shows evidence that the longevity-regulating protein SIRT1 is under the direct control
|
| Regulation Gene |
SIRT1
|
| Year |
2010
|
| Pubmed ID |
20660480
|
| Title |
SIRT1 is regulated by a PPARr-SIRT1 negative feedback loop associated with senescence
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|