Details
| Name | CDKN2A |
| Type | gene |
| Species | Mus musculus |
| Tissue | skeletal muscle,fat |
| Experiment Method | qRT-PCR,knockout,other |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Expression of p16(Ink4a) and p19(Arf) increases with age in both rodent and human tissues. However, whether these tumour suppressors are effectors of ageing remains unclear, mainly because knockout mice lacking p16(Ink4a) or p19(Arf) die early of tumours. |
| Regulation Gene | NA |
| Year | 2008 |
| Pubmed ID | 18516091 |
| Title | Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |