A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name HLA-DRB1
Type SNP
Species Homo sapiens
Tissue blood samples
Experiment Method qPCR
Up/Down Up
Pro/Anti Anti
Funtion Description DRB1*1401, DQB1*0503, DQA1*0101=0104 and DQA1*05 were significantly increased in the centenarians. The significant increase of HLA-DQB1*0503 and/or DQA1*0101=0104 in the centenarians can be explained by a linkage disequilibrium with DRB1*1401, or vice ver
Regulation Gene HLA-DRB1
Year 1997
Pubmed ID 9389323
Title Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity.
Drug NA
Disease NA
Environment Factors NA
Circulating 1
Variant SNP
High-throughput NA