Details
| Name | PDE1A |
| Type | SNP |
| Species | Homo sapiens |
| Tissue | mice with defective nucleotide excision repair gene ERCC1 (Ercc1d/ mice); human VSMCs |
| Experiment Method | Western blot;Quantitative real-time PCR |
| Up/Down | NA |
| Pro/Anti | NA |
| Funtion Description | Senescent human VSMC showed elevated PDE1A and PDE1C and PDE5 mRNA levels (11.6-, 9- and 2.3-fold respectively), which associated with markers of cellular senescence. Conversely, PDE1 inhibition lowered expression of these markers. In summary, these resul |
| Regulation Gene | NA |
| Year | 2015 |
| Pubmed ID | 26464516 |
| Title | Phosphodiesterase 1 regulation is a key mechanism in vascular aging. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |