| Name |
CDKN2A
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
HSCs
|
| Experiment Method |
RT-PCR,enzyme-linked immunosorbent assay (ELISA)
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Mammalian target of rapamycin (mTOR) activity is increased in HSCs from old mice compared to those from young mice. mTOR activation through conditional deletion of Tsc1 in the HSCs of young mice mimicked the phenotype of HSCs from aged mice in various way
|
| Regulation Gene |
NA
|
| Year |
2009
|
| Pubmed ID |
19934433
|
| Title |
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|