| Name |
rs1061170
|
| Type |
SNP
|
| Species |
Homo sapiens
|
| Tissue |
blood samples
|
| Experiment Method |
qPCR
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
Here we demonstrate that CFH binds to oxPLs. The CFH 402Y variant of the protective rs1061170 genotype binds oxPLs with a higher affinity and exhibits a stronger inhibitory effect on the binding of oxPLs to retinal pigment epithelium and macrophages. In a
|
| Regulation Gene |
CFH
|
| Year |
2012
|
| Pubmed ID |
22875704
|
| Title |
Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids
|
| Drug |
NA
|
| Disease |
age-related macular degeneration
|
| Environment Factors |
NA
|
| Circulating |
1
|
| Variant |
SNP
|
| High-throughput |
NA
|