A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name CENP-A
Type gene
Species Homo sapiens
Tissue TIG3
Experiment Method qPCR;Northern blot
Up/Down Down
Pro/Anti Pro
Funtion Description Cellular senescence is an irreversible growth arrest and is presumed to be a natural barrier to tumor development. Like telomere shortening, certain defects in chromosome integrity can trigger senescence; however, the roles of centromere proteins in regul
Regulation Gene NA
Year 2010
Pubmed ID 20160010
Title CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA