| Name |
Chk1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Colorectal cancer cell lines HCT116 wt, HCT116 p53-/-, HCT116 p21-/- and HT29
|
| Experiment Method |
Western blotting;siRNA transfection;Senescence B-galactosidase staining;Fluorescence immunostaining;
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Chk1 knockdown deciphered that Chk1 defines long-term DNA damage responses causing cell cycle re-entry. We propose that recovery from oxidative DNA damage-induced G(2) arrest requires Chk1. It works as cutting edge and navigates cells to senescence or mit
|
| Regulation Gene |
NA
|
| Year |
2011
|
| Pubmed ID |
20716119
|
| Title |
Cutting edge: Chk1 directs senescence and mitotic catastrophe in recovery from G checkpoint arrest.
|
| Drug |
NA
|
| Disease |
colorectal cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|