Details
| Name | rs5746092 |
| Type | SNP |
| Species | Homo sapiens |
| Tissue | blood samples |
| Experiment Method | qPCR |
| Up/Down | NA |
| Pro/Anti | NA |
| Funtion Description | The rs5746092 (-38C>G) and rs2758343 (-299C>A) SNPs alter the affinity of the SOD2 promoter for AP-2a and SP1 respectively. Evidence of an association between the -38C>G SNP and age related hearing loss was detected in the London cohort only; p=0.0436, OR |
| Regulation Gene | SOD2 |
| Year | 2013 |
| Pubmed ID | 23500038 |
| Title | A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss |
| Drug | NA |
| Disease | age-related hearing loss |
| Environment Factors | NA |
| Circulating | 1 |
| Variant | SNP |
| High-throughput | NA |