Details
| Name | Y402H |
| Type | SNP |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | other |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | The FH Y402H polymorphism associated with AMD causes a reduction in binding of FH and FHL-1 to CRP and M protein. Both variants show comparable binding to RPE cells, indicating that AMD is unlikely to manifest as a result of impaired host cell-surface rec |
| Regulation Gene | FHL-1 |
| Year | 2008 |
| Pubmed ID | 18263814 |
| Title | Functional and structural implications of the complement factor H Y402H polymorphism associated with age-related macular degeneration. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | 1 |
| Variant | NA |
| High-throughput | NA |