Details
| Name | 4977-bp deletion |
| Type | somatic mutation |
| Species | Homo sapiens |
| Tissue | lung |
| Experiment Method | reverse-phase |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | Taken together, these results suggest that accumulation of mtDNA with the 4977-bp deletion together with oxidative DNA damage and lipid peroxides is associated with aging and that smoking enhances oxidative damage in human lung tissues. |
| Regulation Gene | 4977-bp |
| Year | 1999 |
| Pubmed ID | 9989940 |
| Title | Concurrent increase of oxidative DNA damage and lipid peroxidation together with mitochondrial DNA mutation in human lung tissues during aging--smoking enhances oxidative stress on the aged tissues. |
| Drug | NA |
| Disease | NA |
| Environment Factors | smoking |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |