A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name 4E-BP
Type somatic mutation
Species Fly Strains
Tissue Flies
Experiment Method Western blot
Up/Down NA
Pro/Anti Anti
Funtion Description In chico heterozygotes, which are robustly long-lived, d4eBP is required but not sufficient to slow aging. Remarkably, d4eBP is not required or sufficient for chico homozygotes to extend longevity. Likewise, chico heterozygote females partially require d4
Regulation Gene NA
Year 2015
Pubmed ID 26252766
Title Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA