Details
| Name | a p16-insensitive mutant |
| Type | somatic mutation |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | Western blots |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | Expression of either cdk4(R24C) or p53DD alone had little effect on life span, but expression of both permitted cells to divide 25 to 43 population doublings (PD) beyond their normal limit. |
| Regulation Gene | p16 |
| Year | 2002 |
| Pubmed ID | 12077343 |
| Title | A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | 1 |
| Variant | somatic mutation |
| High-throughput | NA |