Details
| Name | A673T |
| Type | somatic mutation |
| Species | Homo sapiens |
| Tissue | blood samples |
| Experiment Method | Western Blotting |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | We found a coding mutation (A673T) in the APP gene that protects against Alzheimer's disease and cognitive decline in the elderly without Alzheimer's disease. This substitution is adjacent to the aspartyl protease B-site in APP, and results in an approxim |
| Regulation Gene | APP |
| Year | 2012 |
| Pubmed ID | 22801501 |
| Title | A mutation in APP protects against Alzheimer's disease and age-related cognitive decline |
| Drug | NA |
| Disease | Alzheimer's disease |
| Environment Factors | NA |
| Circulating | 1 |
| Variant | somatic mutation |
| High-throughput | NA |