A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name age-1
Type somatic mutation
Species Caenorhabditis elegans
Tissue NA
Experiment Method PCR
Up/Down differential expression
Pro/Anti NA
Funtion Description Three of four mutant strains studied (MK31, MK542, MK546) contain recessive mutations that significantly lengthen life; MK542 and MK546 consistently fail to complement the long life phenotype of age-1 and are therefore allelic. MK31, although longer lived
Regulation Gene age-1
Year 1988
Pubmed ID 3385139
Title Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA