| Name |
AKI603
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
U937, HL-60, Jurkat and K562, KBM5 and KBM5-T315I cell lines,32D cells
|
| Experiment Method |
CFSE staining;Western blot
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
AKI603 exhibited strong anti-proliferative activity in leukemic cells.AKI603 inhibited cell proliferation and colony formation capacities in imatinib-resistant CML cells by inducing cell cycle arrest with polyploidy accumulation.inhibition of AurA by AKI6
|
| Regulation Gene |
T315I
|
| Year |
2016
|
| Pubmed ID |
27824120
|
| Title |
Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.
|
| Drug |
imatinib
|
| Disease |
chronic myeloid leukemia (CML)
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|