| Name |
BNC1 truncation mutation
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
testis tissue
|
| Experiment Method |
qPCR,Western blot,Microarray
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
In this study, we found that male mice carrying the truncation mutation exhibited progressively fertility loss and testicular premature aging.The truncation mutation disabled nuclear translocation of the BNC1/TAF7L complex, thus disturbing expression of r
|
| Regulation Gene |
bnc1
|
| Year |
2019
|
| Pubmed ID |
31065688
|
| Title |
Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
somatic mutation
|
| High-throughput |
GSE50807
|