| Name |
BRCA1
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
human breast tissue
|
| Experiment Method |
Western blot;Immunoprecipitation;Quantitative RT-PCR;Immunofluorescence;Telomere chromatin immunoprecipitation and qPCR;Immunohistochemistry;GSEA and IPA
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here we show that human mammary epithelial cells (HMECs) from BRCA1-mutation carriers (BRCA1(mut/+)) exhibit increased genomic instability and rapid telomere erosion in the absence of tumour-suppressor loss. Furthermore, we uncover a novel form of haploin
|
| Regulation Gene |
NA
|
| Year |
2015
|
| Pubmed ID |
26106036
|
| Title |
Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.
|
| Drug |
NA
|
| Disease |
breast cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|