Details
| Name | CDK4-Arg24Cys (R24C) |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | NA |
| Experiment Method | Western blot |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | MEFs derived from Cdk4(R24C/R24C) mice displayed decreased doubling times, escape from replicative senescence, and escape sensitivity to contact-induced growth arrest. |
| Regulation Gene | Cdk4 |
| Year | 2002 |
| Pubmed ID | 11756559 |
| Title | Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence. |
| Drug | NA |
| Disease | papillomas |
| Environment Factors | NA |
| Circulating | NA |
| Variant | somatic mutation |
| High-throughput | NA |