Details
| Name | CDK6 |
| Type | somatic mutation |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | PCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | One of the cell lines, SCC4, contains a cdk6 amplification and expresses functional p16ink4a.Ectopic expression of p16ink4a with a recombinant retrovirus in this cell line also induced a similar senescence-like phenotype. |
| Regulation Gene | cdk6 |
| Year | 1998 |
| Pubmed ID | 10030668 |
| Title | Re-expression of endogenous p16ink4a in oral squamous cell carcinoma lines by 5-aza-2'-deoxycytidine treatment induces a senescence-like state. |
| Drug | 5-aza-2-deoxycytidine |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |