A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name DAF-2
Type somatic mutation
Species Caenorhabditis elegans
Tissue C. elegans strains
Experiment Method qPCR
Up/Down NA
Pro/Anti Anti
Funtion Description Mutants in DAF-2 (a homologue of the mammalian insulin receptor) and AGE-1 (a homologue of the catalytic subunit of mammalian phosphatidylinositol 3-OH kinase) arrest development at the dauer stage. Moreover, animals bearing weak or temperature-sensitive
Regulation Gene DAF-2
Year 1997
Pubmed ID 9353126
Title The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant somatic mutation
High-throughput NA