| Name |
Dkc1
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
MEF cells
|
| Experiment Method |
Luciferase assay,Western Blotting
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
We now demonstrate the presence of the growth defect in Dkc1( delta 15) mouse embryonic fibroblasts in vitro and show that accumulation of DNA damage and levels of reactive oxygen species increase with increasing population doublings. Treatment with the a
|
| Regulation Gene |
Dkc1
|
| Year |
2011
|
| Pubmed ID |
21241452
|
| Title |
Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment
|
| Drug |
NA
|
| Disease |
cause X-linked dyskeratosis congenita
|
| Environment Factors |
NA
|
| Circulating |
1
|
| Variant |
somatic mutation
|
| High-throughput |
NA
|