Details
| Name | E2F1 |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | mice strains |
| Experiment Method | qPCR |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | To determine whether E2F-1 deregulation--as a result of loss of pRB--promotes proliferation in vivo, we have tested whether loss of E2f1 interferes with the pituitary and thyroid tumorigenesis that occurs in Rb1(+/-) mice. We have found that loss of E2f1 |
| Regulation Gene | E2F-1 |
| Year | 1998 |
| Pubmed ID | 9537419 |
| Title | Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | somatic mutation |
| High-throughput | NA |