| Name |
G to C
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
primary murine embryonic fibroblasts
|
| Experiment Method |
qPCR,Western blot
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
The p53 mutations selected for during Hupki MEF immortalization have been found in human tumors and are classified in the yeast transactivation assay as transcriptionally defunct, suggesting that disabling this component of p53 activity is crucial in sene
|
| Regulation Gene |
p53
|
| Year |
2010
|
| Pubmed ID |
20118236
|
| Title |
Wild-type and Hupki (Human p53 Knock-in) Murine Embryonic Fibroblasts p53/ARF PATHWAY DISRUPTION IN SPONTANEOUS ESCAPE FROM SENESCENCE
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
somatic mutation
|
| High-throughput |
NA
|