| Name |
GAS2
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
Human immortalized non-tumourigenic liver cell lines(MIHA and LO2) and HCC cell lines (HepG2, Huh7,PLC5, Hep3B, and SK-Hep1); HCC liver tissue samples and The matched non-tumourous liver tissues
|
| Experiment Method |
Chromatin immunoprecipitation microarray(ChIP-chip);reverse transcription-PCR,and western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
HBx delta 35 was found to bind the promoter region of GAS2 and attenuate its expression to promote hepatocellular proliferation and tumourigenicity.GAS2 induces p53-dependent apoptosis and senescence to counteract HBx delta 35-mediated tumourigenesis.Nota
|
| Regulation Gene |
p53
|
| Year |
2015
|
| Pubmed ID |
25925944
|
| Title |
Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.
|
| Drug |
NA
|
| Disease |
hepatocarcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|