| Name |
GSE4
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
F9 and dyskerin-mutated F9 cells (F9-A353V);HEK293T cells (ATCC);DC-C and DC-3 cells;XDC-1787-C (Corriel Cell Repository) and F26IIB cells (generated in our laboratory)
|
| Experiment Method |
Immunofluorescence and immunocytochemistry;Telomeric Repeat Amplification Protocol (TRAP);Quantitative RT-PCR
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
Expression of GSE4 and GSE24.2 significantly decreased cell senescence.GSE24.2 increases telomerase activity and decreases oxidative stress and the DNA damage response in dyskeratosis congenita patient cells. In addition, GSE4 protects F9-A353V dyskerin-m
|
| Regulation Gene |
c-myc and TERT
|
| Year |
2015
|
| Pubmed ID |
26571381
|
| Title |
GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant Cells.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|