| Name |
HRAS
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
NIH 3T3 cells, human fibroblast BJ cells and the Phoenix Ampho and Eco packaging cell lines
|
| Experiment Method |
Luciferase assay,Western Blotting
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
We demonstrated that these mutant HRAS proteins induced senescence when overexpressed in human fibroblasts. Oncogene-induced senescence is a cellular reaction that controls cell proliferation in response to oncogenic mutation and it has been considered on
|
| Regulation Gene |
HRAS
|
| Year |
2011
|
| Pubmed ID |
21850009
|
| Title |
HRAS mutants identified in Costello syndrome patients can induce cellular senescence: possible implications for the pathogenesis of Costello syndrome
|
| Drug |
NA
|
| Disease |
Costello syndrome
|
| Environment Factors |
NA
|
| Circulating |
1
|
| Variant |
somatic mutation
|
| High-throughput |
NA
|