A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name IGF1
Type somatic mutation
Species Homo sapiens
Tissue serum
Experiment Method PCR,other
Up/Down Up
Pro/Anti Pro
Funtion Description Sequence analysis of the IGF1 and IGF1 receptor (IGF1R) genes of female centenarians showed overrepresentation of heterozygous mutations in the IGF1R gene among centenarians relative to controls that are associated with high serum IGFI levels and reduced
Regulation Gene NA
Year 2008
Pubmed ID 18316725
Title Functionally significant insulin-like growth factor I receptor mutations in centenarians.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant 1
High-throughput NA