A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name IGF1R
Type somatic mutation
Species Mus musculus
Tissue embryonic stem cells
Experiment Method qPCR
Up/Down NA
Pro/Anti Pro
Funtion Description In contrast, null mutants for the Igf1r gene die invariably at birth of respiratory failure and exhibit a more severe growth deficiency (45% normal size). In addition to generalized organ hypoplasia in Igf1r(-/-) embryos, including the muscles, and develo
Regulation Gene Igf1r
Year 1993
Pubmed ID 8402901
Title Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant somatic mutation
High-throughput NA