A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name IGF2
Type somatic mutation
Species Mus musculus
Tissue embryonic stem cells
Experiment Method qPCR
Up/Down NA
Pro/Anti Pro
Funtion Description Igf-1(-/-)/Igf1r(-/-) double mutants did not differ in phenotype from Igf1r(-/-) single mutants, while in Igf-2(-)/Igf1r(-/-) and Igf-1(-/-)/Igf-2(-) double mutants, which are phenotypically identical, the dwarfism was further exacerbated (30% normal size
Regulation Gene Igf-2
Year 1993
Pubmed ID 8402901
Title Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant somatic mutation
High-throughput NA