A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name InR
Type somatic mutation
Species Drosophila melanogaster
Tissue fly strains
Experiment Method immunoprecipitation
Up/Down NA
Pro/Anti Anti
Funtion Description We describe a heteroallelic, hypomorphic genotype of mutant InR, which yields dwarf females with up to an 85% extension of adult longevity and dwarf males with reduced late age-specific mortality. Treatment of the long-lived InR dwarfs with a juvenile hor
Regulation Gene InR
Year 2001
Pubmed ID 11292875
Title A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant somatic mutation
High-throughput NA