A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name KL-VS
Type somatic mutation
Species Mus musculus
Tissue HeLa cells
Experiment Method qPCR
Up/Down NA
Pro/Anti Pro
Funtion Description We identified an allele, termed KL-VS, containing six sequence variants in complete linkage disequilibrium, two of which result in amino acid substitutions F352V and C370S. Homozygous elderly individuals were underrepresented in three distinct populations
Regulation Gene KL
Year 2002
Pubmed ID 11792841
Title Association of human aging with a functional variant of klotho.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant SNP
High-throughput NA