| Name |
LMNA
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
HeLa cells,HFF cells,293FT cells
|
| Experiment Method |
Immunoprecipitation and Western blotting;Immunofluorescence
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
The small ubiquitin-related modifier (SUMO) modification (SUMOylation)-defective E203G mutant that is associated with familial dilated cardiomyopathy exhibited abnormal subnuclear distribution and inhibited normal localization of WT lamin A in a dominant-
|
| Regulation Gene |
NA
|
| Year |
2014
|
| Pubmed ID |
25319090
|
| Title |
Long-term expression of the lamin A mutant associated with dilated cardiomyopathy induces senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|