| Name |
LMNA
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
hTERT-TetOff-Pro,hMSCs
|
| Experiment Method |
Western blotting,Immunofluorescence microscopy,Microarrays,other
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
The premature-ageing disease Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by constitutive production of progerin, a mutant form of the nuclear architectural protein lamin A. Progerin is also expressed sporadically in wild-type cells and has been
|
| Regulation Gene |
NA
|
| Year |
2008
|
| Pubmed ID |
18311132
|
| Title |
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
1
|
| High-throughput |
NA
|