| Name |
MDL-1
|
| Type |
somatic mutation
|
| Species |
Caenorhabditis elegans
|
| Tissue |
C. elegans strain
|
| Experiment Method |
Quantitative RT-PCR and ChIP-PCR
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
The deletion allele mdl-1(tm311) shortened lifespan, and did so significantly more so in long-lived daf-2 mutants implying that mdl-1(+) contributes to effects of daf-2 on lifespan. mdl-1 mutant hermaphrodites also lay increased numbers of unfertilized oo
|
| Regulation Gene |
daf-2
|
| Year |
2014
|
| Pubmed ID |
24531613
|
| Title |
MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|