| Name |
mtDNA
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
hepatocytes and liver tissue from a conplastic mouse strain
|
| Experiment Method |
Western blot;Immunofluorescence staining;PCR
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
The C57BL/6NTac-mtNODLtJ mice differed from C57BL/6NTac mice by a point mutation in mitochondrial-encoded subunit 3 of cytochrome c oxidase. Young C57BL/6NTac-mtNODLtJ mice showed reduced mitochondrial metabolism but similar reactive oxygen species (ROS)
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
27890640
|
| Title |
An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|