| Name |
mtDNA complex IV mutation
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
brain
|
| Experiment Method |
Gene expression analysis,Quantification of mitochondrial network structure
|
| Up/Down |
up
|
| Pro/Anti |
pro
|
| Funtion Description |
Taken together, we conclude that it is the complex IV mutation which entails a shorter-lived phenotype with poor physical performance at old age.
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
30376218
|
| Title |
Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|