| Name |
CYLD
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
HAECs and human coronary aortic smooth muscle cells(HCASMCs);Human monocyte cell lines (THP-1 cells);The mouse macrophage cell line RAW264.7
|
| Experiment Method |
RT-PCR;Western blotting
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Intriguingly, CYLD gene expression was significantly reduced in bone marrow-derived macrophages of aged mice compared that of young mice, as well as in senescent HAECs compared with young cells.These findings suggest that age-related attenuation of CYLD e
|
| Regulation Gene |
NA
|
| Year |
2019
|
| Pubmed ID |
30554661
|
| Title |
Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis.
|
| Drug |
0
|
| Disease |
atherosclerosis
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|