Details
| Name | NA |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | Mammary tumors |
| Experiment Method | Western Blotting,qPCR |
| Up/Down | NA |
| Pro/Anti | NA |
| Funtion Description | Here, we show that, contrary to dogma, MMTV-Wnt1 mammary tumors with mutant p53 exhibited a superior clinical response compared to tumors with wild-type p53. Doxorubicin-treated p53 mutant tumors failed to arrest proliferation, leading to abnormal mitoses |
| Regulation Gene | p53 |
| Year | 2012 |
| Pubmed ID | 22698404 |
| Title | p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer |
| Drug | doxorubicin |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | somatic mutation |
| High-throughput | NA |