| Name |
nibrin
|
| Type |
somatic mutation
|
| Species |
Homo sapiens
|
| Tissue |
The spontaneously immortalized T cell lines: S3R and S4,L5 cell line
|
| Experiment Method |
Immunoprecipitation;Western blotting;Immunocytochemistry;Fluorimetric Detection of DNA unwinding (FADU)
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Our results indicate that a substantially reduced level of nibrin or its truncated p70 form is sufficient to induce DNA-damage dependent senescence in VSMCs and S4 cells, respectively.In doxorubicin-treated S3R cells DDR activation was severely impaired,
|
| Regulation Gene |
NA
|
| Year |
2014
|
| Pubmed ID |
25119968
|
| Title |
The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes.
|
| Drug |
doxorubicin
|
| Disease |
Nijmegen Breakage Syndrome
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|