Details
| Name | NSMCE2 |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | The Nsmce2 genetrap strain |
| Experiment Method | Immunofluorescence and immunoblotting;Immunohistochemistry |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | NSMCE2 (Mms21, in Saccharomyces cerevisiae), an essential SUMO ligase of the SMC5/6 complex, suppresses cancer and aging in mice.Surprisingly, a mutation that compromises NSMCE2-dependent SUMOylation does not have a detectable impact on murine lifespan. I |
| Regulation Gene | NA |
| Year | 2015 |
| Pubmed ID | 26443207 |
| Title | NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. |
| Drug | NA |
| Disease | cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |