Details
| Name | null alleles |
| Type | somatic mutation |
| Species | Yeast |
| Tissue | NA |
| Experiment Method | other |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Null alleles of EST1 are not immediately inviable; instead, they have a senescence phenotype, due to the gradual loss of sequences essential for telomere function, leading to a progressive decrease in chromosomal stability and subsequent cell death. |
| Regulation Gene | EST1 |
| Year | 1989 |
| Pubmed ID | 2655926 |
| Title | A mutant with a defect in telomere elongation leads to senescence in yeast. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |