A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name nuo-6
Type somatic mutation
Species Caenorhabditis elegans
Tissue NA
Experiment Method PCR,other
Up/Down Up
Pro/Anti Anti
Funtion Description three C. elegans mitochondrial mutants (clk-1, isp-1 and nuo-6) overlapping genetic pathways that contribute to their longevity and regulated by the FOXO transcription factor DAF-16 are upregulated in all three strains
Regulation Gene NA
Year 2018
Pubmed ID 29522556
Title Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA