A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name OGG1-R304W/R336H
Type somatic mutation
Species Mus musculus
Tissue liver, brain, and testis
Experiment Method PCR
Up/Down Up
Pro/Anti Pro
Funtion Description Among the double mutants was SAMP1, which exhibits accelerated senescence and short lifespan.
Regulation Gene null
Year 2001
Pubmed ID 11369503
Title Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant somatic mutation
High-throughput NA