| Name |
p19 biallelic deletion
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
primary murine embryonic fibroblasts
|
| Experiment Method |
qPCR,Western blot
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
Over half of the cell lines did not reveal evidence of p53 mutation or loss of p19/ARF and retained a robust wild-type p53 response to DNA damage, supporting the inference from senescence bypass screens that alternative genetic routes to immortalization o
|
| Regulation Gene |
p19
|
| Year |
2010
|
| Pubmed ID |
20118236
|
| Title |
Wild-type and Hupki (Human p53 Knock-in) Murine Embryonic Fibroblasts p54/ARF PATHWAY DISRUPTION IN SPONTANEOUS ESCAPE FROM SENESCENCE
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
somatic mutation
|
| High-throughput |
NA
|