| Name |
p53
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
MCF-7 and MDA-MB-231 breast cancer cells;MCF-7/C, MCF-7/Sip53 cells
|
| Experiment Method |
Senescence-associated b-galactosidase staining;Western blot;qRT-PCR
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
p53 knockdown or mutation has a negative effect on metformin or phenformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. p53 reactivating agent nutlin-3a and CP/31398 promoted metformin-induced growth inhibition, senescence a
|
| Regulation Gene |
p53
|
| Year |
2015
|
| Pubmed ID |
26225749
|
| Title |
p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells.
|
| Drug |
metformin or phenformin
|
| Disease |
breast cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|