| Name |
p53
|
| Type |
somatic mutation
|
| Species |
Mus musculus
|
| Tissue |
Murine embryonic fibroblasts
|
| Experiment Method |
Western blot
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Absence of p53-mediated apoptosis, cells undergo cellular senescence to prevent genomic instability.UVR induces p53-p21 driven cellular senescence in the skin of p53R173P mice.
|
| Regulation Gene |
PUMA,NOXA
|
| Year |
2010
|
| Pubmed ID |
20703098
|
| Title |
Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.UVR induces p53-p21 driven cellular senescence in the skin of p53R173P mice.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
UV irradiation
|
| Circulating |
NA
|
| Variant |
somatic mutation
|
| High-throughput |
NA
|