Details
| Name | Pit1 |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | liver |
| Experiment Method | Western blots |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | Our studies suggest that the Pit1 mutation results in a decreased activity of the insulin/IGF-1 pathway; that this plays a key role in the longevity of the Snell dwarf mouse and conforms to the nematode longevity paradigm. |
| Regulation Gene | Pit1 |
| Year | 2002 |
| Pubmed ID | 12020946 |
| Title | Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | somatic mutation |
| High-throughput | NA |