A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name POL2-16
Type somatic mutation
Species Saccharomyces cerevisiae
Tissue NA
Experiment Method CHIP
Up/Down NA
Pro/Anti Pro
Funtion Description The pol2-16 mutant senesces more rapidly than wild type strain and also has shorter telomeres.
Regulation Gene POL2
Year 2002
Pubmed ID 12015307
Title The DNA polymerase domain of pol(epsilon) is required for rapid, efficient, and highly accurate chromosomal DNA replication, telomere length maintenance, and normal cell senescence in Saccharomyces cerevisiae.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant somatic mutation
High-throughput NA