Details
| Name | prelamin A |
| Type | somatic mutation |
| Species | Mus musculus |
| Tissue | NA |
| Experiment Method | qPCR,Illumina HumanHT-12 version 4 beadchip,RNAi |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Mice deficient in Zmpste24, a metalloproteinase mutated in human progeria and involved in nuclear prelamin A maturation, recapitulate multiple features of ageing. However, their short lifespan and serious cell-intrinsic and cell-extrinsic alterations rest |
| Regulation Gene | LMNA |
| Year | 2013 |
| Pubmed ID | 23917225 |
| Title | Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | 1 |
| High-throughput | NA |